I have no idea if she knew Tsuna before he managed to become joker somehow. He was a pain in the ass, generally. Which he still is, whoa! But waaaaaaaaaaay more atrociously acting-outy when he was a teeny.

If she hung out with Athena ever than she most surely knew Tsuna. Although if she did, she probably wouldn't recognize him now which could be kinda fun? Idk.

And with Eli being new they'll just have to build their own cr in game.